(+)-JQ1 from BPS Bioscience, Inc.

Product Specs
Item(+)-JQ1
CompanyBPS Bioscience, Inc.
Price Pricing Info Supplier Page View Company Product Page
Catalog Number27402
Quantity5 mg
Activity(+)-JQ1 has been shown to inhibit BRD4 (BD1) with a Kd of 50 nM, and BRD4 (BD2) with a Kd of 90 nM
Purity≥95% by HPLC
Molecular Weight457.0 Da
FormulaC₂₃H₂₅ClN₄O₂S
TypeInhibitor

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BPS Bioscience, Inc.

6405 Mira Mesa Blvd

Suite 100

San Diego, CA 92121

United States

Phone: 858-202-1401

Email: sales-team@bpsbioscience.com

Company Profile

Website: https://bpsbioscience.com/

(1) ELF3 activated by a superenhancer and an autoregulatory feedback loop is required for high-level HLA-C expression on extravillous trophoblastsProceedings of the National Academy of Sciences of the United States of AmericaMarch 2, 2021Li Q, Meissner TB, Wang F, Du Z, Ma S, Kshirsagar S, Tilburgs T, Buenrostro JD, Uesugi M, Strominger JL.penicillin/streptomycin solution at 37 °C with 5% CO2. For JQ1 treatment experiments, (+)-JQ1 (catalog no. 27402; BPS Bioscience) at 500 nM or an equivalent volume of DMSO were resuspended in fresh medium, added to

(2) Design, synthesis, and evaluation of novel coumarin-dithiocarbamate derivatives (IDs) as anti-colorectal cancer agentsJournal of Enzyme Inhibition and Medicinal ChemistryFebruary 9, 2021Heping Zhu, Shilong Ying, Bingluo Zhou, Xinyang Hu, Xiao Liang, Wangyu Li, Dungai Wang, Hongchuan Jin, Yuanjiang Panwavelength at 615 & 665 nm) was read on EnVision (PerkinElmer, UK). (+)-JQ1 (BPS Bioscience, Cat. No. 27402) was used as a positive control. BRD4-1 (RD-11–157) and BRD4-2 (RD-11–158) were purchased from Reaction Biology Corp

(3) β-Catenin safeguards the ground state of mousepluripotency by strengthening the robustness of the transcriptional apparatusScience AdvancesJuly 17, 2020Meng Zhang et al.ESC maintenance beforehand in the Esteban laboratory. Other inhibitors including JQ1 (BPS Bioscience, 27402), LDC000067 (Selleck Chemicals LLC, S7461), THZ1 (MedChemExpress, HY-80013), and actinomycin D (Sigma-Aldrich,

(4) Maintenance of MYC expression promotes de novo resistance to BET bromodomain inhibition in castration-resistant prostate cancerScientific ReportsDecember 1, 2019Daniel J. Coleman et al.logarithmic growth in 96-well plates and treated the next day with serial dilutions of JQ1 (BPS Bioscience #27402) or OTX-015 (Selleck S7360), in addition to DMSO vehicle, in triplicate wells. Cell viability was measured

(5) Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4Nature medicineOctober 1, 2018Zanconato F, Battilana G, Forcato M, Filippi L, Azzolin L, Manfrin A, Quaranta E, Di Biagio D, Sigismondo G, Guzzardo V, et al.Peprotech. Vemurafenib-PLX4032 (A3004) and THZ1 (A8882) were from Apex Bio. JQ1 was from BPS Bioscience (27402). RG 108 (ab141013) was from Abcam. pCDNA-FLAG-YAP vectors (wild-type or 5SA, siRNA insensitive) were

(6) Signal transducer and activator of transcription STAT5 is recruited to c-Myc super-enhancerBMC Molecular BiologyDecember 1, 2016Sophia Pinz, Samy Unser, Anne Rascletrichostatin A (TSA) were purchased from SIGMA (D-2650 and T-8552 respectively). (+)-JQ1 (BPS Bioscience #27401)—hereafter abbreviated to JQ1—was purchased from BIOMOL GmbH. TSA and JQ1 were dissolved in DMSO at

(7) Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodelingScience SignalingAugust 11, 2016Lomeli R. Carpio et al.matrix staining with Alcian blue. JAK Inhibitor I (1 μM; Millipore, 420097), JQ-1 (1 μM; BPS Bioscience, 27402), IKK2 Inhibitor V (1 μM; Calbiochem, 401481), or vehicle [0.01% (v/v) dimethyl sulfoxide (DMSO)] was

(8) Cellular androgen content influences enzalutamide agonism of F877L mutant androgen receptorOncotargetJune 28, 2016Daniel J. Coleman et al.(DHT) was obtained from Sigma (A8380). For in vitro experiments, JQ-1 was obtained from BPS Bioscience (27402). For in vivo studies, JQ-1 was obtained from the laboratory of Dr. James Bradner, Dana Farber Cancer

(9) Characterization of the genome-wide TLX1 binding profile in T-cell acute lymphoblastic leukemiaLeukemiaDecember 1, 2015K Durinck et al.for 12 h with either DMSO or 1 μM of JQ1 compound (BPS Bioscience, San Diego, CA, USA; catalog number 27401). ALL-SIL cells were seeded at a density of 1 × 106 cells/ml and treated for 48 h with either DMSO or

(10) Deacetylase inhibitors repress STAT5-mediated transcription by interfering with bromodomain and extra-terminal (BET) protein functionNucleic acids researchApril 20, 2015Pinz S, Unser S, Buob D, Fischer P, Jobst B, Rascle A.were purchased from SIGMA (D-2650, T-8552, C-2211 and I-9278, respectively). (+)-JQ1 (BPS Bioscience #27401)—hereafter abbreviated to JQ1—was purchased from BIOMOL GmbH. VPA, apicidin and MS-275 were purchased

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(+)-JQ1

(+)-JQ1

(+)-JQ1 from BPS Bioscience, Inc.

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BPS Bioscience, Inc.

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(+)-JQ1 from BPS Bioscience, Inc.

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